Kwezwa kwa polay cyane muri antibiyotike na c18AQ inkingi

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Porogaramu R & D Centre

Intangiriro
Antibiyotike ni icyiciro cya metabolite ya kabiri cyakozwe na mikorobe (harimo na bagiteri, ibihumyo, actinamycetes) cyangwa ibigo bisa na synthesied chinary cyangwa igice cya kabiri. Antibiyotike irashobora kubuza gukura no kubaho kubindi mikorobe. Antibilitique ya mbere yavumbuwe n'abantu, yavumbuwe na Microbiologuste y'Ubwongereza Alexander Fleandre yahitanye mu 1928. Yabonye ko bagiteri mu bihe bidashobora gukura mu myanya y'umuco staphylococccuc yanduye. Yavuze ko uburyo bugomba kwanga ibintu bya antibacteri, yise penicillin mu 1928. Ariko, ibiyi byose ntibyari byejejwe muri kiriya gihe. Mu 1939, Ernst Roin na Holford Florey wa kaminuza ya Oxford yahisemo guteza imbere ibiyobyabwenge bishobora kuvura indwara za bagiteri. Nyuma yo kuvugana na Fleming kugirango ubone imigenzo, barabikuye neza kandi basukuye penisiline kuva mu migenzo. Kugirango iterambere ryabo rinoze rya penisiline nkibiyobyabwenge, Fleming, urunigi na Florey basangiye igihembo cyitiriwe Nobel mumiti.

Antibiyotike ikoreshwa nk'abakozi ba antibacterial gufata cyangwa gukumira indwara za bagiteri. Hariho ibyiciro byinshi byingenzi bya antibiyotike zikoreshwa nk'abakozi ba antibioile: β-Lacacly antibionics (harimo pentiopique, ephaycherics, ibiti byose bya antibiyotike, n'ibindi byose bya antibiyonic) birimo ibinyabuzima birimo ibinyabuzima birimo ibinyabuzima fermentation, kimwe cya kabiri na synthesis. Antibiyotike ikorwa na Fermenttion yakozwe mu binyabuzima igomba guhinduka neza uburyo bwa shimi bite ku buryo buhamye, ingaruka zuburozi, ibintu bya antibacterie nibindi bibazo. Nyuma yo guhindura imitima, antibiyotike irashobora kugera ku ngaruka zituje, kugabanya ingaruka zidasanzwe, zagabanijwe, zagabanije ibiyobyabwenge, byatumye ibinyabuzima byagabanijwe, byateje imbere ibinyabuzima, bityo bigatuma ingaruka zo kuvura ibiyobyabwenge. Kubwibyo, Antibiyotike ya Semi-Singhiotique iri hemwe hazwi cyane mugutezimbere ibiyobyabwenge bya antibiyotike.

Mu iterambere rya antibiyotike ya kimwe cya kabiri, antibiyotike ifite imitungo yo gukundwa mu buryo bworoshye, ibikomoka ku bicuruzwa n'ibikoresho bigoye kuva bakomoka muri mikorobe. Muri iki gihe, gusesengura no kugenzura umwanda muri antibiyotike ya kimwe cya kabiri ni ngombwa cyane. Kugirango tumenye neza kandi biranga umwanda, birakenewe kubona umwanda uhagije uturutse mubicuruzwa bya sintetike ya antibiyotike ya kimwe cya kabiri. Mubuhanga bwanduye bwanduye, Flash chromatography nuburyo bwiza-bwibiciro hamwe nibyiza nkibinini byinshi byo gupakira, ikiguzi gike, nibindi Flamromatography yarushijeho kuba abashakashatsi ba Sintekoko.

Muri iyi nyandiko, umwanda munini wa semic aminoglycoside antibiotike yakoreshejwe nkurugero kandi isuku na tarridge c18AQ cartridge hamwe na flaroma ya flaromaan ™ imashini. Ibicuruzwa bigamije gusaba ibisabwa byabonetse neza, byerekana igisubizo cyiza cyane cyo kwezwa kuri ibi bice.