Kudziyeretsa kwa polar zodetsa kwambiri pamaantibiotic ndi C18aq Codens

Mingzu yang, Bo xu
Ntchito R & D Center

Chiyambi
Maantibayotiki ndi gulu la ma metabolis (kuphatikiza mabakiteriya, mafanga, actionycection) kapena magawo ofanana omwe amasinthasintha kapena ophatikizika. Maantibayotiki amatha kuletsa kukula ndi kupulumuka kwa tizilombo tina. Mankhwala oyamba omwe atengedwa ndi munthu, penicillin, adapezeka ndi a Mictillin, a Alexander a ku Flexander Fleming mu 1928. Adawona kuti mabakiteriya omwe ali pafupi ndi chipembedzo cha Staphcoccus chomwe chidayipitsidwa ndi nkhungu. Adalemba kuti nkhungu iyenera kutchingira chantibacteriryry, yomwe adatcha penicillin mu 1928. Komabe, zosankhidwa zosagwira sizipangidwa nthawi imeneyo. Mu 1939, Ernst unyolo unyolo ndi Howard Florey of Oxford University adaganiza zopanga mankhwala omwe angagwiritse ntchito mabakiteriya. Pambuyo polumikizana ndi Fleming kuti athe kupeza zovuta, adazichotsa ndi kutsukidwa ndi mbolo. Kuti awopike bwino penicillin ngati mankhwala ochiritsira, othawa, unyolo ndi florey adagawana mphotho ya 1945 ya Nolbel mu mankhwala.

Maantibayotiki amagwiritsidwa ntchito ngati antibacterial othandizira kuti azichitira kapena kupewa mabakiteriya. Pali magulu angapo a maantibayotiki omwe amagwiritsidwa ntchito ngati antibacterial othandizira: β-lactigin (kuphatikiza penicillin, chloglycline, ndi zina mwa mankhwala a macatonicol) synthesis ndi kapangidwe kawiri. Maantibayotiki omwe amapangidwa ndi mphamvu zachilengedwe amafunika kusinthidwa molingana ndi njira zamankhwala chifukwa cha kukhazikika kwamankhwala chifukwa cha zovuta zamankhwala, zoopsa zoyipa, antibacterial perectumu ndi zovuta zina. Pambuyo pakusinthidwa molakwika, maantibayotiki amatha kukhazikika, ochepetsa zoopsa, wowonjezera mankhwala osokoneza bongo, kuchepetsedwa kukana kwa bioavailability, ndipo potero adasintha mphamvu mankhwala. Chifukwa chake, maantibayotiki osapangana ndi chitsogozo chodziwika bwino kwambiri pakupanga mankhwala a antibiotic.

Pakukula kwa maantibayotiki, zopangidwa ndi maantibayotiki zimakhala ndi zinthu zoyera, zinthu zambiri komanso zigawo zina zowonjezera kuyambira pomwe zimachokera ku zinthu zazing'onoting'ono. Pankhaniyi, kusanthula ndi kuwongolera zinthu zosapangidwa mu maantibayotikidwe ndi chinthu chofunikira kwambiri. Kuti muzindikire ndikuwonetsa zosayenera, ndikofunikira kupeza zosayenera zokwanira kuchokera kuzopanga za maantibayotiki a Semi-code. Mwa njira zofala zophatikizira zophatikizira, Flash chromatography ndi njira yotsika mtengo yokhala ndi zabwino monga zitsanzo zazikulu zokulitsa, mtengo wotsika, etc.

Mu positi iyi, kudetsa kwakukulu kwa aminoglycoside mankhwala omwe amagwiritsidwa ntchito ngati chitsanzochi ndikutsukidwa ndi Cleatlash C18aq complegraphy ™ yamakina. Cholinga cha chandamale chomwe chingapangitse zofunazo zidapezeka bwino, kutanthauza yankho labwino kwambiri pakuyeretsa kwa mankhwala awa.