Nā Nūhou

Nūhou

ʻO ka hoʻomaʻemaʻeʻana o kaʻauhauʻauhau e Secuban ™ mīkini

Luna o auhau

Meiyuan qian, yefong tan, bo xu
Noi r & d waena

Hōʻikeʻike
ʻO kaʻauhau kālā He mea kanu a me ka mea kanu i waihoʻia ma hope o nā glaci claciers quaternary. ʻO ia hoʻi wale nō ka lāʻau lapaʻau kūlohelohe maoli i ka honua. Hoʻokuʻuʻia kaʻauhau ma keʻano o ka mahana o keʻano'ākau o ka'ākau i keʻano waena o keʻano waena, me ka hola 11 o 11 mau mea i ka honua. Aia he 4 mauʻano a me 1 mauʻano ma Kina,ʻo iaʻo China Vedit Hoʻomaopopoʻia kēia mauʻanoʻelima ma Southkountʻo China,ʻAmelika Kina, Central Kina, Eastwings Kina, komohana komohana, Northwest China, Northwest China, Northwest China, Northwest China. Loaʻa nā mea kūʻaiʻauhau nui i nāʻano maʻamau o nā kemika, e pili ana i nā lunaʻauhau, nā flavise, nā steities, stequitorspenes a me nā glycoitierpenes a me nā Galkoli. ʻO kaʻauhau nui anti-tumor kaulana He meaʻole nā ​​meaʻauhau antinicer antiniccer. Hiki i kaʻauhau ke "freeze" microtubules e ka hoʻohuiʻana me lākou a pale i nā microtubules mai ka wā e hoʻokaʻawale ai i nā collē. Eia kekahi, ma o ka hanaʻana i nā macrophages, e hōʻemi ai kaʻauhau ma Tnf-α (Tumor Nenutor Creeol [2]. Eia naʻe, hiki i kaʻauhau ke hoʻokūkū i ka apoptossis ma o ka hanaʻana i ke ala spect hou ma ka foreptotic ma kahi o ka foreptot. Ma muli o kona mau hopena Anniclecer, ua hoʻohana nuiʻia kaʻauhau o ka maʻi maʻi maʻi, nā maʻi maʻi maʻi, nā maʻi maʻi maʻi maʻi, a me nā umauma maʻi a me ka'ā'ī Loaʻa i nā mea maʻi maʻi maʻi maʻi no ka maʻi maʻi maʻi ovarian avarian ovarian,ʻo ka haʻaleleʻana o ka curarative, no ka mea, ua kapaʻiaʻo ka hope o ka maʻi maʻi ".

ʻO kaʻauhauʻo ia ka lāʻau lapaʻau nui loa i loko o ka mākeke o ka honua i loko o nā makahiki i hala aku nei a ua manaʻoʻia he mau makahiki anticancer maikaʻi loa i nā makahiki 20 e hiki mai ana. I nā makahiki i hala iho nei, me ka nui o ka ulu pōpilikia, ua hoʻonui nō ia ke koi no kaʻauhau. I kēia manawa, koiʻia kaʻauhau no ke kauka a iʻole ke noiʻiʻepekema i laweʻia pololei mai kaʻauhau. Eia nō naʻe, he haʻahaʻa loa nā manaʻo o kaʻauhau i nā mea kanu i nā mea kanu. ʻO ke ao, he 0 ka meaʻauhauʻauhauʻo 0-1% ma kaʻili o ka Burnfolia,ʻo ia ka mean me ka manaʻo nui e loaʻa i kaʻike kiʻekiʻe loa. No ke kumu o ka 1 G o kaʻauhauʻauhau, pono ia e pili ana i ka 13.6 kg o ka piko. E pili ana i kēia kuhi, e lawe iā 3 - 12 mau lāʻau lāʻau lapaʻau eʻoi aku ma mua o 100 mau makahiki e mālama ai i kahi maʻi maʻi ovarian. Ma muli o kahi hopena, uaʻokiʻia kahi nui o nā lāʻau lāʻau lapaʻau, ua hopena i ka hopena kokoke i kēia mau mea waiwai. Ma kahi o ka mea iʻoi aku ka maikaʻi o nāʻauhau ma nā kumuwaiwai a lohi i ka uluʻana,ʻo ia ka mea paʻakikī no ka hoʻolālā houʻana a me ka hoʻohanaʻana i kaʻauhau hou.

I kēia manawa, ua pau ka synthesis o kaʻauhau kālā. Eia naʻe, he paʻakikī loa ke ala synthetic a me ke kumukūʻai kiʻekiʻe,ʻaʻole ia he mea nui. ʻO keʻano o ke alapine semi-synthetic o kaʻauhau i kēia manawa a ua manaʻoʻia he ala kūpono e hoʻonui ai i ke kumu o kaʻauhau ma kahi o ke kumu kūʻai. E pōkole, i ka semi-synthesis o kaʻauhau, nā mea nui o ka mea kūʻai aku ma kahi nui o nā mea kanu ʻO nā manaʻo o 10-Deactylbaccaccatch ⅲ I nā mea pono o ka balesus baccata hiki ke piʻi i 0.1%. A maʻalahi nā mea pono e hoʻopili hou i nā pahuhopu. No laila,ʻo ka semi-synthesis o kaʻauhauʻauhau ma mua o 10-Deactylbaccaccatch

Kiʻi 1.ʻO ke alaʻo Semi-synthetic ma kahi o kaʻauhau e pili ana i ka 10-Deacetylbaccaccatin ⅲ.

I kēia pou, ua hoʻomaʻemaʻe ka mea kanuʻauhau e ka pūnaehana uila kaulike moladan ʻO ka hālāwai huahana huahana e hui ai i nā pono o ka hoʻomaʻemaʻe a hiki ke hoʻohanaʻia ma ka noiʻiʻana i kaʻepekema.

'Āpana hoʻokolohua
I kēia pou, ua hoʻohanaʻia nā meaʻauhau ma mua o ka hoʻohālike. Ua loaʻa i ka simple simple e ka laweʻana i ka mea kūʻaiʻauhau me ka ethanol. A laila ua hoʻokaʻawaleʻia ka simple raw i dmso a hoʻouka i ka flash carridge. ʻO ka hoʻonohonoho hoʻonohonoho hoʻokolohua o ka laweʻana i ka flash hoʻomaʻemaʻeʻia ma ka papa 1.
Hana

Hana

'Ōlelo nia

Kālāʻo ke kikowaena

12 GRerFlash C18 RP Flash Cartridge

Hauhā

254 NM (ʻike), 280 nm (nānā)

ʻO ka pana kelepona

E hoʻopau i kahi: wai

Solvenol B: Methanol

Ka Holo Waike

15 ml / min

Mālama i ka hoʻoukaʻana

20 mg raw simple i hoʻokaʻawaleʻia i 1 ml dmso

Kahuna

Manawa (min)

Soldnt B (%)

0

10

5

10

7

28

14

28

16

40

20

60

27

60

30

72

40

72

43

100

45

100

Papa 1.ʻO ka hoʻonohonoho hoʻokolohua hoʻokolohua no ka hoʻomaʻemaʻe uila.

Hopena a me nā kūkākūkā
ʻO ka Flash Chromatogram no ke kiʻina hoʻopunipuni mai ka lāʻau lapaʻau i hōʻikeʻia ma ke kiʻi 2. Ma ka nānāʻana i ka chromatogram, ka mea i loaʻa i ka huahana basility. Eia kekahi, uaʻikeʻia ka hana kolohe maikaʻi e nā hua'ōlelo he nui (ʻaʻole i hōʻikeʻia kaʻikepili). E lawe ia ma kahi o 4 mau hola e hoʻopau ai i ka hoʻokaʻawaleʻana i ka hoʻokaʻawaleʻana i ka manual chrisitography me nā kolamu aniani. Ke hoʻohālikelike nei me nāʻano hana manuahi ʻOi aku ka nui o 80% o ka manawa a me ka nui o ka condvent o ka laweʻana ma o ka laweʻana ma ka hana kūpono a hoʻomaikaʻi nui i ka uku hana.

Kiʻi 2.ʻO ka Flash Chromatogram o ka laweʻana i nā kalaiwa mai kaʻauhau.

Kiʻi 3.ʻO ka hoʻohālikelike o keʻano chromatography manual me ka hoʻomaʻemaʻe ponoʻana.
I ka hopena, e hoʻohālikelike ana iā Securflash C18 RP Flash Cardidges e hiki ke hāʻawi i ka mīkini wikiwiki e like me ka mea kūʻai aku i ka wikiwiki.
Nā manaʻo aʻoaʻo

1.ʻO Alushin GM, Lander GC, Kelingg Eh, Zhang R MemDututural GRITTUNTER GOCTUTIBUNTER CHANDETURANS. CELL, 2014, 157 (5), 1117-1129.
2, Burkhart ca, Berman JW, Swaindell CS a me Hoewitz SB. Ka pilina ma waena o keʻano o kaʻauhau a me nāʻauhau'ē aʻe i ke komoʻana o ka tumor necrosis factory a me ka cytotoinity. Nā noiʻi celecer, 1994, 54 (22), 5779-5782.
3. Wiki sj, w ʻO kaʻauhauʻauhau kalaiʻi-10-hilinaʻi Apotossis, J. Bili. Chem., 2004, 279, 51057-51067.
4. Palitaxel. ʻO ke kulaʻAmelika o nā Gammacists olakino olakino. [Ianuali 2, 2015]
5.ʻO Bruce Ganm lāuaʻo Roland R. Franke. ʻO Paclitaxel mai nāʻauhau mua J. Org. Chem., 2007, 72 (11), 3981-3987.

E pili ana i nā c18 rp flash flash cardidges

Aia kekahi mau papa o ka hoʻokaʻawaleʻana i ka c18 rp flash flash cardidges me nā kiko'ī'ē aʻe mai kaʻenehana Satai mai kaʻenehana Satai (e like me ka hōʻikeʻana ma ka Papa 2).

Helu helu

Ka nui o ka kolamu

Ka Holo Waike

(ml / min)

Max.pressure

(psi / bar)

Sw-5222-004-sp

5.4 G

5-15

400 / 27.5

Sw-5222-012-sp

20 g

10-25

400 / 27.5

Sw-5222-025-sp

33 G

10-25

400 / 27.5

Sw-5222-040-sp

48 G

15-30

400 / 27.5

Sw-5222-080-sp

105 g

25-50

350 / 24.0

Sw-5222-120-sp

155 g

30-60

300 / 20.7

Sw-5222-220-sp

300 g

40-80

300 / 20.7

Sw-5222-330-sp

420 g

40-80

250 / 17.2

Papa 2. E hoʻokaʻawale iā C18 RP Flash Cartridges.
Nā Mea Hacking: He kiʻekiʻe kiʻekiʻe o Spherrical Sphericright C18-BILDADED SILACIIC, 20 - 45 μm, 100 Å

No kaʻike hou aku ma nā kiko'ī kiko'ī o Secritations o Secubean ™ i ka mīkini, a iʻole ka'ōlelo kauoha ma Securflash Series, e kipa aku i kā mākou pūnaewele


Post Times: Sep-20-2018