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ʻO ka hoʻomaʻemaʻeʻana i nā mea nui o nā polar nui ma nā antibiotics e nā kolamu C18AQ

ʻO ka hoʻomaʻemaʻeʻana i nā mea nui o nā polar nui ma nā antibiotics e nā kolamu C18AQ

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Noi r & d waena

Hōʻikeʻike
ʻO nā antibiotics kahi papa o nā metabilita lua i hanaʻia e nā microorganins i hanaʻia Hiki i nā antibiotics ke hoʻonāukiuki i ka ulu a me ke olaʻana o nā microorganisms'ē aʻe. Uaʻikeʻia ka antibiotic mua e ke kanaka, pencichin, iʻikeʻia e nā microbiologist o Alexander ma 1928. Nānāʻiaʻo ia i keʻano o ka papa'āina Poshilatleloʻo ia e hoʻomaopopo i ka moll i mea e hūnā i kahi mea antibacterial antibaibalan i kapaʻiaʻo Penichilin i 1928,ʻaʻole naʻe,ʻaʻole naʻe,ʻaʻole naʻeʻo ia ua hoʻomaʻemaʻeʻia nā pono hana ma ia manawa. I ka makahiki 1939, Erst Chain a me Howard Florey City Central City e hoʻoholo e hoʻomohala i kahi lāʻau lapaʻau i hiki ke hoʻomaikaʻi i nā maʻi maʻi. Ma hope o ka hoʻopiliʻana i ka fleming e kiʻi i nā hana, ua kūleʻa lākou a mālamaʻia a hoʻomaʻemaʻeʻia No kā lākou holomua kūleʻa o Pencillin e like me ka lāʻau lapaʻau lāʻau lapaʻau, cleming, chan and florey shared i ka lāʻau lapaʻau 1945

Hoʻohanaʻia nā antibiotics e like me nā mea antibacterial antibacterial e mālama ai a pale paha i nā maʻi bacterial. Aia kekahi mau helu nui o nā antibiotics i hoʻohanaʻia e like me nā antibiotika antibiotika,ʻo nā kumulāʻau antibiotika. Dertevate, semi-synthesis a me ka synthesis a me ka synthesis. ʻO nā antibiotics i hanaʻia e ka fermentation friend e pono e hoʻonohonohoʻia e nā hana chectical ma muli o keʻano o ka pono o ka chemtical ma muli o nā hopena heihei. Ma hope o ka loliʻana o ka moloili, hiki i nā antibiotics ke hoʻonui i ka hopena, hoʻemi i nā hopena he nui, hoʻololiʻia i ke kūleʻaʻana, a me keʻano maʻiʻoi aku ka hoʻomaʻamaʻaʻana, a me ka hopena maikaʻi o ka lāʻau lapaʻau. No laila,ʻo nā SEMI-Synthetic Synthetic i kēia manawa ke kiʻi kaulana loa i ke kūkuluʻana i ka hoʻomohalaʻana o nā lāʻau lapaʻau antibiotic.

I ka hoʻomohalaʻana o ka semi-synthetic antibiotics, he antibiotics i nā waiwai haʻahaʻa, he nui nā huahana mai ko lākou mau huahana fertetation fertetation fertetation. I kēia hihia,ʻo ka nānāʻana a me ka kāohiʻana o nā meaʻino i nā mea nui semi-synthetic antibiotics he mea nui loa ia. I mea e noʻonoʻo pono ai a hōʻike i nā haumia, pono ia e loaʻa i kahi nui o nā mea nui mai nā huahana synthetic o nā lāʻau semi-synthetic antibiotika. I waena o ka hana hoʻomākaukau maʻamau maʻamau,ʻo nā'ōnaehana blash clromatoika no ka hanaʻoi aku ka maikaʻi o ka hana nui, a me nā hana hou aʻe e like me ka ukuʻana iā SWELL.

I kēia pou, ua hoʻohanaʻia ka nui o ka nui o ka simup i ka maninikonacoino i ka maʻi antibiotcoino i ka sportrlato Ua loaʻa ka hālāwai huahana huahana i loaʻa i nā koi, e hōʻike ana i kahi hopena maikaʻi loa no ka hoʻomaʻemaʻeʻana o kēia mau pūpū.

'Āpana hoʻokolohua
Ua hāʻawiʻia keʻano hoʻohālike e ka hui pūʻana o ka lāʻau lapaʻau kūloko. Heʻanoʻanoʻano hoʻohālikeʻo Amino Polycyclites a me kānaʻano molecular e like me ka huiʻana me ka aminoglycois antibiotika. ʻOi aku ka kiʻekiʻe o ka lapalapa o nā lāna o nā kiʻina, e hoʻohilahila loa i ka wai. Ua hōʻikeʻia ka kiʻi kiʻi kiʻi o keʻano molecular o ka molecular i hōʻikeʻia ma ke kiʻi 1.ʻO ka maʻemaʻe o ka hoʻohālike e pili ana i ka 88% e like me ka hipc. No ka hoʻomaʻemaʻeʻana o kēia mau pūpū o nā pūpū kiʻekiʻe, e paʻa mauʻia keʻano ma nā kolamu C18 e like me kā mākou mau hanana mua. No laila, ua hanaʻia kahi kolamu C18Aq no ka hoʻomaʻemaʻeʻana.

Kiʻi 1.ʻO ke kiʻi kiʻi kiʻi kiʻi o keʻano molecular o ka molecular.
E hoʻomākaukau i ka hopena sample, 50 mg chede simple i hoʻokaʻawaleʻia ma ka 5 ml mū i ka wai maʻemaʻe a laila e lilo ia i wahi kūponoʻole. ʻO ka hopena sample e hoʻopiliʻia i loko o ke kolamu flash ʻO ka hoʻonohonoho hoʻokolohua o ka laweʻana i ka Flash hoʻomaʻemaʻeʻia i papa inoaʻia ma ka papa 1.

Hana

Secubeean ™ mīkini 2

Nā cartridges

12 GRE SerrFlash C18AQ RP Flash Cartridge, 20 - 45μM, 100 Å - AQ))

Hauhā

204 nm, 220 nm

ʻO ka pana kelepona

E hoʻopau i kahi: wai

Solvend B: Actonitrile

Ka Holo Waike

15 ml / min

Mālama i ka hoʻoukaʻana

50 mg

Kahuna

Manawa (min)

Soldnt B (%)

0

0

19.0

8

47.0

80

52.0

80

Hopena a me nā kūkākūkā
Ua hōʻikeʻia ka Flash Chiprotogram o keʻano o ka c18aq ma ke kāleka 2. E like me ka hōʻikeʻana ma ke kiʻi 2 Ma hope o LyPHOHization no nā mea i hōʻiliʻiliʻia, ua hoʻomaʻemaʻe ka huahana o ka mea kūʻai mai 96.2% (e like me ke kiʻi 3) ʻO nā hopena i hōʻikeʻia ua hoʻohana houʻia ka huahana iʻikeʻia ma ka noiʻi e hiki mai ana a me ka hoʻomohalaʻana.

Kiʻi 2.ʻO ka Flash Chromatogram o ka hoʻohālike ma kahi pahu C18AQ.

Kiʻi 3.ʻO ka HPLC Chromatogram o ka huahana i hoʻopaʻaʻia.

I ka hopena, hoʻokaʻawale iā C18AQ RP Flash Carridge i hui pūʻia me ka'ōnaehana Flash chromano

E pili ana i ka chearflash c18aq rp flash cardidges
Aia kekahi mau papa o ka moku i hoʻokaʻawale iā C18AQ RP Flash Carridges me nā kiko'ī likeʻole mai kaʻenehana Satai (e like me ka hōʻikeʻana ma ka Papa 2).

Helu helu

Ka nui o ka kolamu

Ka Holo Waike

(ml / min)

Max.pressure

(psi / bar)

SW-5222-004-SP (AQ)

5.4 G

5-15

400 / 27.5

SW-5222-012-SP (AQ)

20 g

10-25

400 / 27.5

SW-5222-025-SP (AQ)

33 G

10-25

400 / 27.5

SW-5222-040-SP (AQ)

48 G

15-30

400 / 27.5

SW-5222-080-sp (AQ)

105 g

25-50

350 / 24.0

SW-5222-120-SP (AQ)

155 g

30-60

300 / 20.7

SW-5222-220-SP (AQ)

300 g

40-80

300 / 20.7

SW-5222-330-aq)

420 g

40-80

250 / 17.2

Papa 2. Hoʻokaʻawale i nā c18aq rp flash cardidges. Nā Mea'Ikuhi

No kaʻike hou aku ma nā kiko'ī kiko'ī o Sectivations o Secubean ™ mīkini, a iʻole ka'ōlelo kauoha ma Securflash Serings, e kipa aku i kā mākou pūnaewele.


Post manawa: Oct-26-2018