Tsarkakewa na Cafar Cafar Ta Sepabia ™

Meiyyaan Qian, Yuefieng Tan, BO XU
Aikace-aikacen R & D Cirini

Shigowa da
HAGUS (HAXSSISSISSISS ko Sinanci Yew) tsire-tsire na daji ne da ƙasar. Shuka ne mai wuya kuma mai haɗari ya bar shi a baya ta hanyar Glaciers. Hakanan shine kawai tsire-tsire na asali na duniya. Ana rarraba taxus a cikin wani yanayi mai yanayi na arewa na hemisphere zuwa yankin tsakiyar, tare da kusan nau'ikan 11 a duniya. Akwai nau'ikan guda 4 da kuma 1 iri-iri a cikin Arewa, wato Arbus na Arewa, Yunnan Hifus, Haraji, Tibetan Hipus da Kudancin Haɗa kai da Kudancin Haɗa kai. Wadannan nau'ikan guda biyar ana rarraba su a kudu maso yammacin kasar Sin, China, ta tsakiya ta Tsakiya, Gabashin China, arewa maso gabashin China, arewa maso gabashin Sin da taiwan. Tsire-tsire na haraji sun ƙunshi abubuwan da aka gyara iri-iri, gami da dakuna, flavonoids, sesquoids, phenolic acid da glycosides da glycisides da glycosides da glycisides. Shahararren Anti-Tashi na Tashi (ko Paclitaxel) wani irin takure ne. Haraji yana da hanyoyin rigakafi na musamman. Haraji na iya "daskarewa" microtoubules ta hanyar hada su da kuma hana microtoubules daga rabuwa da sel sel, musamman m yaduwar cutar sel [1]. Bugu da ƙari, ta hanyar kunna Macrophages, Haɗa haraji yana haifar da raguwa a cikin TNF-α (kumburin ƙwayar cuta) waɗanda suke karɓa da sakin TNF-α, don haka kisan kai ko inchophiited tumo. Haka kuma, Haraji na iya shigar da apoptosis ta hanyar aiki akan hanyoyin da aka tsara a shirye-shirye da sauri / Fastl ko kunna tsarin da aka girka Cysteine ​​[3]. Saboda yawan maganin maganin cuta masu yawa, Haraji ana amfani da Haraji sosai a cikin cutar kansa na ovarian, cancantar cutar kanshi, cututtukan mahaifa, cutar kansa da kuma cutar kansa, da sauransu [4]. Musamman don cututtukan nono na ci gaba da cutar cututtukan daji, Hanya tana da babban tasirin warkarwa, saboda haka an san shi "layin ƙarshe na tsaro na cutar kansa".

Haraji shine mafi shahararrun ƙwayoyi na maganin anticationer a kasuwar kasa da duniya a cikin 'yan magunguna masu maganin anticomer na mutane a cikin shekaru 20 masu zuwa. A cikin 'yan shekarun nan, tare da haɓakar haɓakar jama'a da rashin daidaituwa na mutane, buƙatar haraji ya kuma ƙara ƙaruwa sosai. A halin yanzu, Hatsara da ake buƙata don binciken kimiyya ko bincike ana fitar da shi kai tsaye daga taxus. Abin takaici, abin da ke tattare da haraji a tsire-tsire na da ƙima. Misali, abun ciki na Haraji ne kawai 0.069% a cikin haushi na taksi na taxus Bresvifolia, wanda aka yi la'akari da samun mafi girman abun ciki. Don hakar 1 g na haraji, yana buƙatar kimanin 13.6 kilogiram na taxus hausa. Dangane da wannan kimanta, yana ɗaukar bishiyoyi na haraji 3 - 12 waɗanda suka fi shekara 100 don su bi da cutar kansa ta ovarias. A sakamakon haka, an sare yawancin itatuwa naxus an sare shi, yana haifar da lalacewar wannan nau'in halitta mai tamani. Bugu da kari, taksi ba shi da kyau sosai cikin albarkatu da jinkirin girma, wanda ya sa ya zama da wahala don ci gaba da amfani da haraji.

A halin yanzu, an sami nasarar kammala harajin haraji. Koyaya, hanyar roba tana da matukar hade da babban farashi, sanya ba shi da mahimmancin masana'antu. Hanyar Hanya ta Semi-roba ta hanyar haraji yanzu mun girma kuma ana ɗaukarsa ya zama hanya mai inganci don fadada tushen hayemol ban da dasa wucin gadi. A takaice, a cikin Semi-kira na Hishima, harajin Cibiyar Precurrarsor wanda yake da yawa a cikin tsire-tsire masu haraji an fitar da shi sannan ya juya zuwa haraji ta hanyar siminti ta hanyar siminti. Abubuwan da ke cikin 10-deacetylbacatin ⅲ a cikin allurai na biyan haraji na iya zama 0.1%. Kuma allura suna da sauki don sake farfado da kayan sunaye. Sabili da haka, Semi-Synthesis na HAGOL dangane da 10-deacetylbacatin ⅲ yana jan hankalin more rayuwa da yawa daga masu bincike [5] (kamar yadda aka nuna a hoto 1).

Hoto 1

A cikin wannan post, an cire cire kayan haraji ta hanyar walƙiya mai ɗorewa na Flash shirye-shiryen cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan cututtukan fata na C18 Juyawa. Ana samun ganawar samfurin da aka yi amfani da shi kuma ana iya amfani dashi a cikin binciken kimiyya, yana ba da ingantaccen bayani don saurin abubuwan da ke cikin halitta.