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Tsarkakewa da ƙarancin rashin girman bakin ciki a cikin maganin rigakafi ta C18AQ

Tsarkakewa da ƙarancin rashin girman bakin ciki a cikin maganin rigakafi ta C18AQ

Mingzu Yang, BO XU
Aikace-aikacen R & D Cirini

Shigowa da
Kwayoyin rigakafi sune aji na sakandare da ƙananan ƙwayoyin cuta (gami da ƙwayoyin cuta, fungi, likitocinsu) ko kuma makamancin mahimmancin su ne ko kuma semi-singnthemeized ko semi-sernthhezem ko semi-sernthhezed ko semi-sernthhezem. Kwayoyin rigakafi na iya hana ci gaban da kuma rayuwa na wasu ƙananan ƙwayoyin cuta. Eniciotic na farko da ɗan adam da ɗan adam da aka gano cewa masanin microbish, Alexander Steming a cikin 1928. Ya lura cewa ƙwayoyin cuta ba zai iya girma a cikin staphylococcus wanda aka gurbata da mold. Ya sanya moldakin cewa dole ne a rufe kayan antiger a cikin 1928. Koyaya, kayan aikin ba a tsarkake su ba a lokacin. A cikin 1939, Ernst Sarkar da Hoard Flory na Jami'ar Oxford ya yanke shawarar haɓaka magani wanda zai iya magance cututtukan ƙwayar cuta. Bayan tuntuɓar jirgi don samun juzu'i, sun sami nasarar fitar da penifififi da tsarkakakken penialillin daga jiki. Don cin nasarar penillin a matsayin maganin warkewa, fleming, sarkar da Florey sun raba kyautar Nobel ta 1945 a magani.

Ana amfani da rigakafi azaman ƙwayoyin cuta don maganin ko hana cututtukan ƙwayar cuta. Akwai manyan nau'ikan rigakafin rigakafi da aka yi amfani da su azaman ƙwayoyin cuta na ƙwayoyin cuta, cututtukan rigakafin ƙwayoyin rigakafi, da sauransu, da sauransu. Semi-kira da duka kira. Abubuwan rigakafi da aka samar da shi ta hanyar ferolication nazarin halittu yana buƙatar tsari ta hanyar hanyoyin kariya saboda tasirin guba, tasirin enibact da sauran batutuwa. Bayan an gyara Chemically, ƙwayoyin rigakafi na iya cimma haɓaka kwanciyar hankali, rage abubuwan sha-daɗi, suna haɓaka ƙwayar cuta, don hakan yana haifar da tasirin magani. Saboda haka, maganin ƙwayar cuta na ruhu a halin yanzu shine mafi shahararren hanyar a cikin ci gaban magungunan rigakafi.

A cikin ci gaban rigakafin kwayoyin halitta, maganin rigakafi suna da kaddarorin ƙarancin tsarkakakku, da yawa daga cikin samfuran tunda an samo su daga samfuran fermentation. A wannan yanayin, bincike da sarrafa imppurities a cikin rigakafin kwayoyin halitta yana da mahimmanci musamman. Domin dacewa gano da kuma nuna rashin jituwa, ya zama dole a sami isasshen adadin abubuwan sha daga rijiyoyin roba na roba. Daga cikin dabarun da aka yi amfani da shi na yau da kullun, hanya ce mai inganci tare da fa'idodi kamar babban farashi mai yawa, mai ƙarancin farashi, adreshin lokaci, da sauransu Flash Flash Fust.

A cikin wannan post, babban ƙazantar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta ƙwanƙwasa ta ƙwanƙwasa a matsayin samfurin Sepabuan ™ Cartrabling sepagian ™. An sami nasarar samun damar yin nasarar da aka yi nasarar da ake buƙata, ba da shawarar mafita ga tsarkakewar waɗannan mahadi.

Sashi na gwaji
An samar da samfurin da aka samar da samfurin magunguna. Samfurin wani irin amino polyclic carbohydrydrater da tsarin kwayoyin ta sun yi kama da maganin rigakafi. Polarity samfurin ya kasance mai girma, yana sanya shi narkewa cikin ruwa. An nuna zane mai tsari na tsarin kwayar halitta na samfurin samfurin samfurin 1. Tsarkin albarkatun ƙasa ya kusan 88% kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ce kamar yadda HPLC ta yi. Don tsarkake wadannan mahimman abubuwan da aka samu a kan ginshiƙan C18 na yau da kullun gwargwadon abubuwan da muka gabata. Sabili da haka, ana amfani da shafi na C18AQ na C18AQ don tsarkake samfurin.

Hoto 1
Don shirya mafita samfurin, an narkar da samfurin 50 mg a cikin 5 ml tsarkakakken ruwa sannan sannan ultrailonicated domin ya zama cikakken bayani cikakke. Daga nan sai a allurar samfurin samfurin a cikin allon filasha ta hanyar bushewa. Saitin gwaji na walƙiya wanda aka jera a cikin tebur 1.

Kayan aiki

Na Satalan ™ inji 2

Kera

12 G

Igiyar ruwa

204 nm, 220 nm

Aikin hannu

Don haka sauran: Ruwa

Subvent b: acetonitrile

Rate

15 ml / min

Samfuran Loading

50 mg

M

Lokaci (min)

Da yawa b (%)

0

0

19.0

8

47.0

80

52-0

80

Sakamakon da tattaunawa
A cikin cramomatorrogram na samfurin a kan C18aq Callexge da aka nuna a cikin Hoto na 2. Kamar yadda aka nuna a cikin Hoto na 2, mafi kyawun samfurin samfurin da aka riƙe akan C18aq Cartridge sosai. Bayan lyopholization ga brovors crictions, samfurin manufa yana da tsarkakakken 96.2% (kamar yadda aka nuna a hoto na 3) ta bincike na HPLC. Sakamakon ya nuna cewa za'a iya amfani da samfurin da aka tsarkaka a bincike na mataki na gaba.

Hoto na 2. Flash Chromatogram na samfurin a kan C18aq Cartridge.

Hoto na 3. HPLC Chromatogram na samfurin manufa.

A ƙarshe, rabuwa C18AQ RP Flash Cartrge ya hade tare da ingantaccen bayani don tsarkakewa samfuran samfurori sosai.

Game da Commashashash C18aQ RP Flash Carridges
Akwai jerin jeri na C18aQ RP filashin katako tare da bayanai daban-daban daga fasahar Santai (kamar yadda aka nuna a Tebur na 2).

Lambar abu

Girman shafi

Rate

(ml / min)

Max.pressure

(psi / Bar)

SW-5222-004-SP (AQ)

5.4 g

5-15

400 / 27.5

SW-5222-012-SP (AQ)

20 g

10-25

400 / 27.5

SW-5222-025-S (AQ)

33 g

10-25

400 / 27.5

Sw-522-040-sp (AQ)

48 g

15-30

400 / 27.5

Sw-522-080-sp (AQ)

105 g

25-50

350 / 24.0

SW-5222-120-SP (AQ)

155 g

30-60

300 / 20.7

SW-5222-20-SP (AQ)

300 g

40-80

300 / 20.7

SW-522230-SP (AQ)

420 g

40-80

250 / 17.2

Tebur 2. Komawa C18AQ RP Flash Carridges. Packing kayayyaki: ingantaccen feshin C18 (AQ) -Bonded silica, 20 - 45 μm, 100 å.

Don ƙarin bayani game da bayanai dalla-dalla na SepBean ™ Injin, ko kuma yin odar yin oda a kan flayflash jerin filasha walƙiya filasha.


Lokaci: Oct-26-2018